Computational Regulatory Genomics

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• Identifying RBP Targets with RIP-seq

Identifying RBP Targets with RIP-seq

Hans-Hermann Wessels,  Antje Hirsekorn,  Uwe Ohler,  Neelanjan Mukherjee 
Methods Mol. Biol. 2016 1358 None 141--152 DOI   PubMed  

Abstract

Throughout their lifetime RNA molecules interact with a variety of RNA-binding proteins (RBPs). RBPs control gene expression by regulating splicing, polyadenylation, editing, transport, stability, and translation of RNA. There are ~1500 RBPs encoded by the human genome and recent studies have detected ~1100 proteins directly interacting with polyadenylated RNA. Identifying the RNAs bound by RBPs will continue to provide important insights into the regulation of gene expression.