Are you sure you want to delete:
<< Sustained-input switches for transcription factors and microRNAs are central building blocks of eukaryotic gene circuits >> ?
<<
YES >> <<
NO >>
Sustained-input switches for transcription factors and microRNAs are central building blocks of eukaryotic gene circuits
M. Megraw,
S. Mukherjee,
Uwe Ohler
Genome Biol.
2013
14 8 R85
DOI
PubMed
Abstract
WaRSwap is a randomization algorithm that for the first time provides a practical network motif discovery method for large multi-layer networks, for example those that include transcription factors, microRNAs, and non-regulatory protein coding genes. The algorithm is applicable to systems with tens of thousands of genes, while accounting for critical aspects of biological networks, including self-loops, large hubs, and target rearrangements. We validate WaRSwap on a newly inferred regulatory network from Arabidopsis thaliana, and compare outcomes on published Drosophila and human networks. Specifically, sustained input switches are among the few over-represented circuits across this diverse set of eukaryotes.
Additional info
Source code and data
